NONMEM Users Network Archive

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Pediatric Collaborators Sought

From: Nick Holford <n.holford>
Date: Sat, 02 Dec 2006 20:09:16 +1300


We are exploring maturation of aminoglycoside clearance with age in
neonates/children and trying to disentangle development from size changes. In
order to investigate maturation we would like to compile a large data set
looking at renal function with age.

We already have quite a lot of data describing aminoglycoside total clearance
from which we have tried to deduce renal function but it would be much more
satisfying to get some actual measurents of renal clearance -- creatinine,
inulin, drugs -- and/or measurements of GFR.

We have located a large data set in the literature but unfortunately the
authors, though willing, are unable to find the numbers again. So we are
starting over again and seeking help from anyone who would like to contribute
their data, no matter who small the numbers, that would let us build (and
keep building) a data set that can be used to describe the maturation of
renal function as well as the changes with body size.

If you are interested in helping us by adding your own data to a pool we
would be very grateful if you would contact us to discuss how to do this.

Brian Anderson

Nick Holford

Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
Received on Sat Dec 02 2006 - 02:09:16 EST

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