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RE: Absorption delay NOT completed before the next dose is given

From: Alison Boeckmann <alisonboeckmann>
Date: Mon, 02 Apr 2007 07:13:55 -0700

It does seem as though PREDPP should allow doses to be given at a
certain small interval yet the entire sequence is lagged by a larger
amount of time.
If you can do this with a series of dose records, then the ADDL feature
should be usable to do the same thing.
The question is:
Does this restriction represent a genuine impossibility (e.g., it can't
be made to work because of some difficulty in the math),
or was it a programming problem (too difficult to implement), or just a
lapse in thinking on my part many years ago?
I have to go back and review the code and some old memos, and try to
reconstruct what the issue was.
This may take me a week or two because I am traveling right now, but I
will look at it when I can and will report back to the group.

On Mon, 2 Apr 2007 08:28:05 -0400, "Bachman, William (MYD)"
<bachmanw
> My guess is that the software designer simply did not include this
> functionality. When you are engineering software there are a number of
> factors that come into play:
>
> 1. is a given feature plausible?
> 2. is the probability of anyone needing this feature high?
> 3. what is the difficulty of adding this feature? (from easy no-brainer
> to exceedingly difficult and not worth the effort).
> 4. does the addition of the feature run the chance of breaking a lot of
> the currently working features?
>
> The above comments are given without reference to "lag time should not
> exceed the (length of the) interdose interval" but are meant to point
> out that although a given user may desire a specific item, more goes
> into the decision than the users specific need.
>
> ________________________________
>
> From: owner-nmusers
> On Behalf Of Samtani, Mahesh [PRDUS]
> Sent: Saturday, March 31, 2007 6:04 PM
> To: nmusers
> Subject: [NMusers] Absorption delay NOT completed before the next dose
> is given
>
>
> Dear NM users,
>
> NM help files says the following about ALAG
>
>
>
> "When additional doses are specified on a dose event record, the
> absorption lag time applies to the dose and to all the additional doses.
> In this case the lag time should not exceed the (length of the)
> interdose interval"
>
>
>
> My questions are
> a) Why doesn't ADDL work for the above specific case?
> b) I am running linear models with ADVAN2 and ADVAN5 and absorption
> delay is NOT completed before the next dose is given. Due to the problem
> stated above I am not using ADDL. Instead I have a dosing record at
> every time a dose enters the depot compartment. Will this circumvent the
> problem stated above? In other words does ALAG always have to be smaller
> than II and why?
>
>
>
> Please advice...MNS
>
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--
  Alison Boeckmann
  alisonboeckmann
Received on Mon Apr 02 2007 - 10:13:55 EDT

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