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RE: Bayesian estimation example

From: Serge Guzy <GUZY>
Date: Thu, 12 Apr 2007 08:59:26 -0700

A standard population PK approach would be appropriate.
Serge Guzy
President, CEO, POP-PHARM
-----Original Message-----
From: owner-nmusers
On Behalf Of Tausif Ahmed
Sent: Thursday, April 12, 2007 4:03 AM
To: nmusers
Subject: RE: [NMusers] Bayesian estimation example

Dear Group members,

I will make my objective more clear- I have a drug X in which I have
information in healthy volunteers with extensive sampling done, single
dose (12-14 samples).

I have data on appx. 100 volunteers at different dose levels from phase
I studies.

We also have a data in 16 patients at one dose only, with extensive

Now we have data from 200 patients, with 2-3 blood samples collected
from each patient at different doses.
It is also seen that the PK changes in patients.
What I am interested is that can we use Bayesian estimates, (and I think
posthoc estimate from NONMEM, as Yaning mentions) to determine the
pharmacokinetics (PK) of the whole population from these 2-3 blood
samples collected per patient.
Hope it is more clear.
I have checked at website- ( suggested by many
but could not find any control stream on Bayesian. Can the group help me
on this.
I thank the experts for giving their comments on the same. =

Tausif Ahmed Ph.D.
Metabolism and Pharmacokinetics Department

Ranbaxy Research Lab India

-----Original Message-----
From: Wang, Yaning [

Sent: Wednesday, April 11, 2007 8:30 PM
To: Nick Holford; Tausif Ahmed
Subject: RE: [NMusers] Bayesian estimation example

Tausif may be referring to the posthoc estimate from NONMEM (empirical
Bayesian estimate).

-----Original Message-----
From: owner-nmusers
On Behalf Of Nick Holford
Sent: Wednesday, April 11, 2007 10:43 AM
To: Tausif Ahmed
Cc: nmusers
Subject: Re: [NMusers] Bayesian estimation example


Why do you want to use Bayesian Estimation? If you have only just
started to use NONMEM then perhaps you have misunderstood the reasons
for using it. It is very rarely needed.


> Dear Group members,

> I have recently started using NONMEM for population analysis.
> I need you help in understanding Bayesian estimation using NONMEM.
> Can any body provide me a sample control stream along with data file
(Excel or csv format) and also explain the output.
> I use Visual NM to run NONMEM version V.

> Thanking you in anticipation.

> Regards
> Tausif Ahmed Ph.D.
> Metabolism and Pharmacokinetics Department Ranbaxy Research Lab India

Nick Holford, Dept Pharmacology & Clinical Pharmacology University of
Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand

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Received on Thu Apr 12 2007 - 11:59:26 EDT

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