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From: Silke.Dittberner
Date: Fri, 13 Apr 2007 11:33:15 +0200

Dear Amy,
4 different doses were given orally, therefore F1 is fixed to 1.
Below you find the code, hope this helps you,
Thanks again,
Silke

$PK
;--------------Absorption parameters-------------------
   F1 = THETA(1)
   KA = THETA(2)
;--------------Disposition parameters-------------------
   V2 = THETA(3)
   Q3 = THETA(4)
   V3 = THETA(5)
   CL = THETA(6)

;--------------Binding parameters-----------------------
   BMAX = THETA(7) ; concentration of binding parameters in central =
cmt
   KD = THETA(8) ; affinity constant
   AMAX2 = THETA(9) ; amount of binding parameters in peripheral cmt =
     
   S2=V2

AMAX=BMAX*S2
K1=KD*V2
K2=KD*V3
K20=CL/V2
K23=Q3/V2
K32=Q3/V3

$DES
; Protein binding in central compartment
;----------------------------------------------------------
LIN1 = -K20*A(2)+K32*A(3)-K23*A(2)+KA*A(1)
BIND1 = AMAX*K1/(A(2)+K1)**2

; Protein binding in peripheral compartment
;----------------------------------------------------------
LIN2 = K23*A(2)-K32*A(3)
BIND2 = AMAX2*K2/(A(3)+K2)**2

DADT(1)= -KA*A(1)
DADT(2)=LIN1/(1+BIND1)
DADT(3)=LIN2/(1+BIND2)


Received on Fri Apr 13 2007 - 05:33:15 EDT

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