NONMEM Users Network Archive

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Re: RE: batches with different half-life - linear PK

From: nonmem
Date: Thu, 19 Apr 2007 16:04:26 +0000 (GMT)

 
Hello Bill,
 
Covariates change from subject to subject. I believe that a covariate is a constant for one patiant, i.e. a covariate is the same for every dose and for every observation. Please, correct me if I am wrong and every dose for the same subject can have its own half-life, bioavailability, Ka, etc.
 
Thank you,
Pavel


----- Original Message -----
From: Bachman, William
Date: Thursday, April 19, 2007 11:45 am
Subject: RE: [NMusers] batches with different half-life - linear PK
To: nonmem

> maybe I am missing something here, but, why don't you
> parameterize your
> model in terms of half-life and put BATCH as a covariate on half-life?
>
> ________________________________
>
> From: owner-nmusers
> nmusers
> Sent: Thursday, April 19, 2007 10:54 AM
> To: nmusers
> Subject: [NMusers] batches with different half-life - linear PK
>
>
> Hello NONMEM Users,
>
> Sometimes the same subjects receive the same drug from different
> batches. Potentially, half-life can be different accross batches.
> Theoretically, it is easy to model if PKis linear because NONMEM
> superimposes single-dose processes to obtain predicted concentrations
> for multiple doses. Does enyone know how to implement it in NONMEM?
> Are there any classes or publications which can help?
>
> Thanks!
> Pavel
>
>
>
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Received on Thu Apr 19 2007 - 12:04:26 EDT

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