NONMEM Users Network Archive

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Re: RE: batches with different half-life - linear PK

From: nonmem
Date: Thu, 19 Apr 2007 17:13:19 +0000 (GMT)

I'll definately do it!!! I did not expect NONMEM to be so smart....
Pavel


----- Original Message -----
From: Bachman, William
Date: Thursday, April 19, 2007 1:04 pm
Subject: RE: [NMusers] batches with different half-life - linear PK
To: nonmem

> maybe I am missing something here, but, why don't you
> parameterize your
> model in terms of half-life and put BATCH as a covariate on half-life?
>
> ________________________________
>
> From: owner-nmusers
> nmusers
> Sent: Thursday, April 19, 2007 10:54 AM
> To: nmusers
> Subject: [NMusers] batches with different half-life - linear PK
>
>
> Hello NONMEM Users,
>
> Sometimes the same subjects receive the same drug from different
> batches. Potentially, half-life can be different accross batches.
> Theoretically, it is easy to model if PKis linear because NONMEM
> superimposes single-dose processes to obtain predicted concentrations
> for multiple doses. Does enyone know how to implement it in NONMEM?
> Are there any classes or publications which can help?
>
> Thanks!
> Pavel
>
>
>
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Received on Thu Apr 19 2007 - 13:13:19 EDT

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