NONMEM Users Network Archive

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RE: batches with different half-life - linear PK

From: Abutarif, Malaz <malaz.abutarif>
Date: Thu, 19 Apr 2007 17:39:07 -0400

Just out of curiosity, why would a different batch cause a different
half life?
Are we talking about proteins/large molecules?

Malaz A. AbuTarif,
B.Sc. (Pharmacy), Ph.D., G.C.P.M., M.B.A.
Principal Scientist, Schering- Plough Research Institute
2015 Galloping Hill Rd, K-15-2-2650
Kenilworth, NJ 07033
Tel: (908) 740-3835, Fax: (908) 740-2916

        -----Original Message-----
        From: owner-nmusers
        Sent: Thursday, April 19, 2007 11:45 AM
        To: nonmem
        Subject: RE: [NMusers] batches with different half-life - linear
        maybe I am missing something here, but, why don't you
parameterize your model in terms of half-life and put BATCH as a
covariate on half-life?


        From: owner-nmusers
        Sent: Thursday, April 19, 2007 10:54 AM
        To: nmusers
        Subject: [NMusers] batches with different half-life - linear PK
        Hello NONMEM Users,
        Sometimes the same subjects receive the same drug from different
batches. Potentially, half-life can be different accross batches.
Theoretically, it is easy to model if PKis linear because NONMEM
superimposes single-dose processes to obtain predicted concentrations
for multiple doses. Does enyone know how to implement it in NONMEM?
Are there any classes or publications which can help?

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Received on Thu Apr 19 2007 - 17:39:07 EDT

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