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NONMEM VI Intermediate level workshop - US location in Washington, DC

From: Andrew Hooker <andrew.hooker>
Date: Sat, 21 Apr 2007 13:19:15 +0200

Second announcement:
NONMEM Intermediate Workshop - New features and advanced methods for =
building and evaluation in NONMEM VI

Washington, D.C., June 18-20th, 2007
The Center for Drug Development Science (CDDS)
The Beacon Hotel & Corporate Quarters
1615 Rhode Island Ave. NW
Washington, DC 20036

The Center for Drug Development Science (CDDS) is happy to announce the
NONMEM Intermediate Workshop co-sponsored with the pharmacometrics group =
Uppsala University. The Uppsala group has been involved in developing =
models and methodology for over fifteen years. During the last decade =
have been involved in the testing and evaluation of NONMEM VI as it has =
developed and several research projects have focused on new =
functionality in
NONMEM VI. In parallel, diagnostics for model building have been =
evaluated and integrated into NONMEM VI-adapted versions of the programs
Perl-speaks-NONMEM (PsN) and Xpose 4 (described below). In this course =
Uppsala group will present some of the most exciting new features of =
VI and how these tools can be used in the development and evaluation of
non-linear mixed effects models.
Agenda (3 full days):
The course will last for 3 days and consists of both lectures and =
computer exercises. Participants will use NONMEM VI, PsN and Xpose 4. =
and Xpose 4 are freeware and may be installed on participants' computers =
use after the course. In addition to the agenda below consultation =
will be offered during each day of the course.

Day 1: Model building and diagnostics using NONMEM VI
      - Introduction to new features of NONMEM VI
      - Introduction to diagnostics for NONMEM runs
      - Improved model building and diagnostics using PsN and XPOSE 4
      - Automation of NONMEM runs
      - Shrinkage and Empirical Bayes estimates based diagnostics
      - Residual based diagnostics (conditional weighted residuals)
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 2: Computer intensive model building and diagnostics using NONMEM VI =

      - Simulation based reference diagnostics
      - Visual and numerical predictive checks
      - Bootstrapping
      - Case deletion diagnostics
      - Additional new features of NONMEM VI
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 3 - Advanced methods in NONMEM VI
      - Nonparametric estimation in NONMEM VI
      - Semi-parametric estimation in NONMEM VI
      - Prior functionality in NONMEM VI
      - Simultaneous Modeling of Continuous and Categorical Data
      - Handling Data below the Quantification Limit (BQL)
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Having used NONMEM with an understanding of population PK-PD modeling =
having attended a NONMEM basic workshop

Prof. Mats Karlsson
Mats Karlsson is professor of Pharmacometrics at Uppsala University, =
where he leads a research group of about twenty modelers. He received =
PhD in pharmacokinetics from this university in 1989 and has been a =
fellow at University of Glasgow and University of California, San =
and a visiting professor at Georgetown University, Washington DC. He has
received the Giorgio Segre Prize from EUFEPS and is editor for the =
of Pharmacokinetics and Pharmacodynamics. His research interests focus =
methodological aspects of non-linear mixed effects model building and
applied PKPD modeling. He has published over one hundred original =
articles in the area of PK and PKPD.

Dr Andrew Hooker
Andrew Hooker is an assistant professor of pharmacometrics at Uppsala
University, Sweden. Andrew received his PhD in Bioengineering from the
University of Washington, Seattle, USA in 2003, and then moved to Sweden =
a Pfizer post-doctoral fellow at Uppsala University. His research =
on methodological problems associated with building and evaluating
pharmacometric models as well as optimal experimental design. Andrew is =
primary developer of both Xpose 4 and the optimal design program PopED. =

Dr Lars Lindbom
Lars Lindbom is a researcher in Pharmacometrics at Uppsala University,
Sweden. He received his PhD in pharmacokinetics and drug therapy from
Uppsala University in 2006. He is leading the development of

Rada Savic
Rada Savic joined the Pharmacometric research group at Uppsala =
Sweden in 2003 after receiving her pharmacist degree from University of
Belgrade, Serbia. Since then, she has been actively working on =
new features of NONMEM VI. Her research interests focus on nonparametric
methods for population analysis, improved diagnostics for NONMEM VI and
development of new absorption models.

The course will emphasize hands on training, with the participants =
on their own computers. All programs will run from an USB memory-stick =
participants will not be required to install any programs on their =
NOTE: All participants must bring their own laptops.

Xpose 4 is a model building aid for population analysis using NONMEM. =
produces various plots and analyses to facilitate data set checkout,
goodness-of-fit analysis, model exploration and visualization, model
diagnostics, candidate covariate identification and model comparison. =
4 is written in the programming language R with a modular and object
oriented design and allows for integration into nearly any model =
platform. New functionality in Xpose 4 allows the user to create =
based reference diagnostics, compute the conditional weighted residuals =
modify standard Xpose graphics to create publication quality figures. =
4 also makes use of the new features in NONMEM VI including the
visualization of non-parametric parameter distributions and individual
objective function contributions. Xpose is freely available at

Perl-speaks-NONMEM (PsN) is a collection of Perl modules and programs =
in the development of non-linear mixed effect models using NONMEM. The
functionality ranges from simpler tasks such as parameter estimate
extraction from output files, data file sub setting and resampling, to
advanced computer-intensive statistical methods. PsN includes both
stand-alone tools as well as development libraries for method =
PsN is freely available at

Workshop location:
The Beacon Hotel:
1615 Rhode Island Ave. NW, Washington, DC.
Tel: 202-296-2100
Directly across the street from The Center for Drug Development Science,
UCSF, 1608 Rhode Island Ave. NW.

Nearby hotels:

1) Holiday Inn Washington Central, 1501 Rhode Island Ave. NW, =
DC., across Scott Circle from the Workshop location. A room block has =
reserved for course registrants. Tel: 1-800-248-0016 and specify NONMEM
course-UCSF or register online at A reduced room rate =
will be
available until May 23, 2007 or until no rooms are available. The =
Inn Washington-Central/White House is conveniently located on the corner =
15th St and Rhode Island Ave, 2 blocks from the workshop hotel. The =
hotel is
within walking distance of 2 Metro stations, within 1 mile of Amtrak, =
and 4
miles from Reagan National Airport and the Pentagon. The Holiday Inn
Washington offers free high speed Internet and fitness center. The =
Inn is minutes from Washington DC area attractions, including the
Smithsonian museums, Library of Congress, National Zoo, MCI Center,
Washington Monument, US Capitol, Washington DC Convention Center, and
Washington National Cathedral.

2) Marriott Courtyard Embassy Row, 1600 Rhode Island Ave. NW, =
Washington, DC
directly next door to CDDS, University of California, Washington, DC.
Located on Scott Circle in the heart of downtown DC the Courtyard =
Row is an easy walk to DuPont Circle, the K Street business district and =
White House. Stay connected with the free high speed internet in our
oversized guest rooms, and sleep well on the 11 inch plush mattresses
sumptuously appointed with 300 thread-count sheets and down comforters. =

Workshop Organizing Committee:
Julie Nelson, CDDS-UCSF, Washington DC: julie.nelson
Howard Lee, CDDS-UCSF, Washington DC: howard.lee
Nancy Sambol, CDDS-UCSF, San Francisco: nancy.sambol

Registration Fees:

Industry: $2,300
Reduced fees for Academic/Gov't: $1,600

Registration fees include: syllabus; morning and afternoon refreshment
breaks and lunches plus an evening reception.

- Attendance is strictly limited to 50.
- Number of "reduced fees" for Academics and students is limited
- Registration and academic fees will be offered first come, first =

To register online visit

Enrollment is limited to 50, so prospective participants are encouraged =
register well in advance.

Andrew Hooker, Ph.D.
Assistant Professor of Pharmacometrics
Div. of Pharmacokinetics and Drug Therapy
Dept. of Pharmaceutical Biosciences
Uppsala University
Box 591
751 24 Uppsala
Tel: +46 18 471 4355

Received on Sat Apr 21 2007 - 07:19:15 EDT

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