NONMEM Users Network Archive

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RE: Two dependent variables

From: Stephen Duffull <stephen.duffull>
Date: Wed, 31 Jan 2007 09:42:38 +1300

Hi

> Hello,
> I was wondering if I could model two DVs simultaneously with
> the same control stream.
> Like have to equations A=(equation)
> B= (equation)
>
> I have data for two different drugs from same patients Could
> I do it nomem ?

This is somewhat of a large question. Quite simply: yes you can model
several drugs simultaneously in NONMEM. If they have the same structural
model (e.g. both 2 cpt) then this makes life simpler, but otherwise using
the ODE solver ADVANs (6, 9) or the linear algebra solutions (ADVANs 5, 7)
you can pretty much do anything you like...

Our group has modelled 5 linked drugs simultaneously in NONMEM - I can't see
that there's a limit other than on runtimes :-)

Cheers

Steve

--
Professor Stephen Duffull
Chair of Clinical Pharmacy
School of Pharmacy
University of Otago
PO Box 913 Dunedin
New Zealand
E: stephen.duffull
P: +64 3 479 5044
F: +64 3 479 7034

Design software: www.winpopt.com
  

> -----Original Message-----
> From: owner-nmusers
> [mailto:owner-nmusers
> Sent: Wednesday, 31 January 2007 7:41 a.m.
> To: nmusers
> Subject: [NMusers] Two dependent variables
>
> Hello,
> I was wondering if I could model two DVs simultaneously with
> the same control stream.
> Like have to equations A=(equation)
> B= (equation)
>
> I have data for two different drugs from same patients Could
> I do it nomem ? and if yes how do I do it?
>
> Any help is appreciated,
> Thanks
>
>
Received on Tue Jan 30 2007 - 15:42:38 EST

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