NONMEM Users Network Archive

Hosted by Cognigen

Re: parent drug and metabolite

From: Nick Holford <n.holford>
Date: Mon, 05 Mar 2007 15:31:11 +1300

The TRANS1 is unnecessary with ADVAN6. It is effectively ignored by NM-TRAN. It does not mean that NM-TRAN will look for a variable called CL.

David Foster wrote:
>
> I agree with Sam,
>
> Getting rid of TRANS1 would help - as I undertand it, it isnt needed
> with ADVAN6 and that's why the model is looking for CL.
>
> Regards,
>
> David
>
> David Foster, PhD
> Lecturer
> School of Pharmacy and Medical Sciences
> Room P4-08
> City East Campus
> University of South Australia
> Adelaide SA 5000
> CRICOS Provider Number: 00121B
> Phone: 61 8 8302 2055
> Fax: 61 8 8302 2389
> Email: david.foster
>
> Note: This message (including any attachments) is confidential and is
> intended only for the individual(s) named. If you have received it by
> mistake, please let the sender know by e-mail reply and delete it from
> your system.
>
>
>
> > -----Original Message-----
> > From: owner-nmusers
> > [mailto:owner-nmusers
> > Sent: Monday, 5 March 2007 4:18 AM
> > To: nmusers
> > Subject: [NMusers] parent drug and metabolite
> >
> > Dear All:
> >
> > why do I get following error message with the following code?
> > Any opinions regarding this problem and code will be highly
> > appreciated.
> > Thank you very much for your consideration and help. I am
> > modeling parent drug and active metabolite at the same time
> > with this code.
> >
> >
> > AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
> >
> > AN ERROR WAS FOUND ON LINE 13 AT THE APPROXIMATE POSITION NOTED:
> > CL1=THETA(1)*EXP(ETA(1))
> > X
> > THE CHARACTERS IN ERROR ARE:
> > 202 FORTRAN SYNTAX IS INCORRECT OR INAPPROPRIATE IN THIS CONTEXT.
> > 4
> >
> >
> > $PROBLEM Parent drug & active metabolite ;Units: Time=mins,
> > Concentration=uM(umols/L), Amount=umols
> > ;Age=yrs,
> > Weight=kg $DATA AW2.CSV IGNORE=C $INPUT ID TIME DV ANUM AMT
> > SEX WT AGE CMT EVID MDV
> >
> > $SUBROUTINE ADVAN6 TRANS1 TOL=5
> > $MODEL
> > COMP=(PARENT) COMP=(METAB1) COMP=(METAB2)
> >
> > $PK
> > CL1=THETA(1)*EXP(ETA(1))
> > V1=THETA(2)*EXP(ETA(2))
> > K20=THETA(3)*EXP(ETA(3))
> > Q=THETA(4)*EXP(ETA(4))
> > V2=THETA(5)*EXP(ETA(5))
> > V3=THETA(6)*EXP(ETA(6))
> > S1=V1
> > S2=V2
> > K12=CL1/V1
> >
> > $DES
> > DADT(1)=-CL1*A(1)/V1
> > DADT(2)=CL1*A(1)/V1+Q/V3*A(3)-Q/V2*A(2)-K20*A(2)
> > DADT(3)=Q/V2*A(2)-Q/V3*A(3)
> >
> > $ERROR
> > W=F
> > IPRED=F
> > IRES=DV-IPRED
> > IWRES=IRES/W
> > P1=0
> > IF(CMT.EQ.1)P1=1
> > P2=0
> > IF(CMT.EQ.2)P2=1
> > Y1=W*(1+ERR(1))
> > Y2=W*(1+ERR(2))
> > Y=P1*Y1+P2*Y2
> >
> > $THETA
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > $OMEGA
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> > $SIGMA
> > (0,,0.1000E+07)
> > (0,,0.1000E+07)
> >
> > $ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC
> >
> > $COVARIANCE
> >
> > $TABLE ID TIME DV ANUM AMT SEX WT AGE CMT EVID MDV IPRED
> > IWRES NOPRINT ONEHEADER FILE=OUTAMIWR.FIT
> >
> > ID Time DV Anum AMT Gender WT Age CMT
> > 1 0 0 1 3371.43 F 110.23 44 1
> > 1 1 187 1 0 F 110.23 44 1
> > 1 1 14.24 1 0 F 110.23 44 2
> > 1 5 85.55 1 0 F 110.23 44 1
> > 1 5 28.49 1 0 F 110.23 44 2
> > 1 15 12.1 1 0 F 110.23 44 1
> > 1 15 13.43 1 0 F 110.23 44 2
> > 1 30 1.03 1 0 F 110.23 44 1
> > 1 30 3.25 1 0 F 110.23 44 2
> > 1 45 1.19 1 0 F 110.23 44 2
> > 1 60 0.83 1 0 F 110.23 44 2
> > 1 120 0.4 1 0 F 110.23 44 2
> > 1 180 0.35 1 0 F 110.23 44 2
> > 1 240 0.13 1 0 F 110.23 44 2
> >
> > Zheng
> >
> >
> >

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
Received on Sun Mar 04 2007 - 21:31:11 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.