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NONMEM Intermediate Workshop VI

From: Andrew Hooker <andrew.hooker>
Date: Fri, 16 Mar 2007 18:46:13 +0100

(3rd try to send this mail...sorry for the spam if you get multiple copies!)

What: NONMEM Intermediate Workshop: New features and advanced methods for
model building and evaluation in NONMEM VI

Washington, D.C., June 18-20th, 2007
The Center for Drug Development Science (CDDS) The Beacon Hotel & Corporate
1615 Rhode Island Ave. NW
Washington, DC 20036

The Center for Drug Development Science (CDDS) is happy to announce the
NONMEM Intermediate Workshop co-sponsored with the pharmacometrics group at
Uppsala University. The Uppsala group has been involved in developing NONMEM
models and methodology for over fifteen years. During the last decade they
have been involved in the testing and evaluation of NONMEM VI as it has been
developed and several research projects have focused on new functionality in
NONMEM VI. In parallel, diagnostics for model building have been developed,
evaluated and integrated into NONMEM VI-adapted versions of the programs
Perl-speaks-NONMEM (PsN) and Xpose 4 (described below). In this course the
Uppsala group will present some of the most exciting new features of NONMEM
VI and how these tools can be used in the development and evaluation of
non-linear mixed effects models.
Agenda (3 full days):
The course will last for 3 days and consists of both lectures and hands-on
computer exercises. Participants will use NONMEM VI, PsN and Xpose 4. PsN
and Xpose 4 are freeware and may be installed on participants' computers for
use after the course. In addition to the agenda below consultation sessions
will be offered during each day of the course.

Day 1 - Model building and diagnostics using NONMEM VI with PsN and XPOSE 4
      - Introduction to new features of NONMEM VI
      - Improved model building and diagnostics using PsN and XPOSE 4
      - Automation of NONMEM VI runs
      - Introduction to diagnostics for NONMEM VI runs
      - Shrinkage and Empirical Bayes estimates based diagnostics
      - Simulation based reference diagnostics
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 2 - Model building and diagnostics using NONMEM VI with PsN and XPOSE 4
      - Conditional weighted residuals
      - Bootstrapping
      - Case deletion diagnostics
      - Visual and numerical predictive checks
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 3 - Advanced methods in NONMEM VI
      - The use of prior information on parameter values in NONMEM
      - Using nonparametric parameter estimation in model building using
      - Simultaneous modeling of continuous and categorical data
      - Handling data below the limit of quantification (BLQ)
      - Hands-on computer exercises with NONMEM VI, PsN and Xpose

Having used NONMEM with an understanding of population PK-PD modeling and/or
having attended a NONMEM basic workshop

Prof. Mats Karlsson
Mats Karlsson is professor of Pharmacometrics at Uppsala University, Sweden
where he leads a research group of about twenty modelers. He received his
PhD in pharmacokinetics from this university in 1989 and has been a research
fellow at University of Glasgow and University of California, San Francisco,
and a visiting professor at Georgetown University, Washington DC. He has
received the Giorgio Segre Prize from EUFEPS and is editor for the Journal
of Pharmacokinetics and Pharmacodynamics. His research interests focus on
methodological aspects of non-linear mixed effects model building and
applied PKPD modeling. He has published over one hundred original research
articles in the area of PK and PKPD.

Dr Andrew Hooker
Andrew Hooker is an assistant professor of pharmacometrics at Uppsala
University, Sweden. Andrew received his PhD in Bioengineering from the
University of Washington, Seattle, USA in 2003, and then moved to Sweden as
a Pfizer post-doctoral fellow at Uppsala University. His research focuses
on methodological problems associated with building and evaluating
pharmacometric models as well as optimal experimental design. Andrew is a
primary developer of both Xpose 4 and the optimal design program PopED.

Dr Lars Lindbom
Lars Lindbom is a researcher in Pharmacometrics at Uppsala University,
Sweden. He received his PhD in pharmacokinetics and drug therapy from
Uppsala University in 2006. He is leading the development of

Rada Savic
Rada Savic joined the Pharmacometric research group at Uppsala University,
Sweden in 2003 after receiving her pharmacist degree from University of
Belgrade, Serbia. Since then, she has been actively working on evaluating
new features of NONMEM VI. Her research interests focus on nonparametric
methods for population analysis, improved diagnostics for NONMEM VI and
development of new absorption models.

The course will emphasize hands on training, with the participants working
on their own computers. All programs will run from an USB memory-stick and
participants will not be required to install any programs on their computer.
NOTE: All participants must bring their own laptops.

Xpose 4 is a model building aid for population analysis using NONMEM. Xpose
produces various plots and analyses to facilitate data set checkout,
goodness-of-fit analysis, model exploration and visualization, model
diagnostics, candidate covariate identification and model comparison. Xpose
4 is written in the programming language R with a modular and object
oriented design and allows for integration into nearly any model building
platform. New functionality in Xpose 4 allows the user to create simulation
based reference diagnostics, compute the conditional weighted residuals and
modify standard Xpose graphics to create publication quality figures. Xpose
4 also makes use of the new features in NONMEM VI including the
visualization of non-parametric parameter distributions and individual
objective function contributions. Xpose is freely available at

Perl-speaks-NONMEM (PsN) is a collection of Perl modules and programs aiding
in the development of non-linear mixed effect models using NONMEM. The
functionality ranges from simpler tasks such as parameter estimate
extraction from output files, data file sub setting and resampling, to
advanced computer-intensive statistical methods. PsN includes both
stand-alone tools as well as development libraries for method developers.
PsN is freely available at

Hotel Workshop and City:
Workshop location:
The Beacon Hotel:
1615 Rhode Island Ave. NW, Washington, DC. Tel: 202-296-2100; directly
across the street from The Center for Drug Development Science, UCSF, 1608
Rhode Island Ave. NW.

Sleeping Rooms:

1) Holiday Inn Washington Central, 1501 Rhode Island Ave. NW, Washington,
DC. , across Scott Circle from the Workshop location. A room block has been
reserved for course registrants. Tel: 1-800-248-0016 and specify NONMEM
course-UCSF or register online at A reduced room rate will be
available until May 23, 2007 or until no rooms are available. The Holiday
Inn Washington-Central/White House is conveniently located on the corner of
15th St and Rhode Island Ave, 2 blocks from the workshop hotel. The hotel is
within walking distance of 2 Metro stations, within 1 mile of Amtrak, and 4
miles from Reagan National Airport and the Pentagon. The Holiday Inn
Washington offers free high speed Internet and fitness center. The Holiday
Inn is minutes from Washington DC area attractions, including the
Smithsonian museums, Library of Congress, National Zoo, MCI Center,
Washington Monument, US Capitol, Washington DC Convention Center, and
Washington National Cathedral.

2) Marriott Courtyard Embassy Row, 1600 Rhode Island Ave. NW, Washington,
DC directly next door to CDDS, University of California, Washington, DC.
Located on Scott Circle in the heart of downtown DC the Courtyard Embassy
Row is an easy walk to DuPont Circle, the K Street business district and the
White House. Stay connected with the free high speed internet in our
oversized guest rooms, and sleep well on the 11 inch plush mattresses
sumptuously appointed with 300 thread-count sheets and down comforters. Tel:

Workshop Organizing Committee:
Julie Nelson, CDDS-UCSF, Washington DC: julie.nelson
CDDS-UCSF, Washington DC: howard.lee
Francisco: nancy.sambol

Registration Fees:

Industry: $2,300
Reduced fees for Academic/Gov't: $1,600

Registration fees include: syllabus; morning and afternoon refreshment
breaks and lunches plus an evening reception.

- Attendance is strictly limited to 50.
- Number of "reduced fees" for Academics and students is limited to a total
of 8.
- Registration and academic fees will be offered on the basis of first come,
first served

To register online visit
Enrollment is limited to 50, so prospective participants are encouraged to
register well in advance.

Andrew Hooker, Ph.D.
Assistant Professor of Pharmacometrics
Div. of Pharmacokinetics and Drug Therapy
Dept. of Pharmaceutical Biosciences
Uppsala University
Box 591
751 24 Uppsala
Tel: +46 18 471 4355

Received on Fri Mar 16 2007 - 13:46:13 EDT

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