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FW: NONMEM Tips #23 - December 21, 2006 - Installing NONMEM VI on a MacBook Pro under OS X --> UPDATE March 26, 2007

From: Bachman, William <bachmanw>
Date: Mon, 26 Mar 2007 14:32:13 -0400

Marc Gastonguay (Metrum) has reported that there is a version of g95
specific to the MacBook Pro under OS X available that uses the Intel
machine constants (g95-x86-osx.tgz). (We originally reported a version
that originated for the Power PC and used the IEEE constants).

It is our recommendation that the g95 version specific to the MacBook
Pro under OS X available (using the Intel machine constants) should be
used for running NONMEM and PDx-Pop for the Mac (g95-x86-osx.tgz).

Icon Development Solutions
6031 University Blvd., Suite 300
Ellicott City, MD 21043
Phone 410-696-3098

-----Original Message-----
From: Gastonguay, Marc [mailto:marcg
Sent: Friday, January 05, 2007 12:15 PM
To: Bachman, William (MYD)
Cc: Bill Knebel; Tim Bergsma
Subject: Re: [NMusers] NONMEM Tips #23 - December 21, 2006 - Installing
NONMEM VI on a MacBook Pro under OS X

We successfully implemented your suggested options for a NMVI
installation on Intel MacBook Pro (similar specs to yours, but 2 GHz and

2GB RAM) with the following differences:
1) Intel constants
2) x86 OSX g95 compiler (g95-x86-osx.tgz) found at

NONMEM installation was run using the SETUP utility, although we also
plan to try this with NMQUAL.

We've only run a couple of models, but looks good so far. We were also
successful with an INFN subroutine (older tests with gfortran indicated
a bug with include statements in the INFN, but that is not a problem
with g95). We'll let you know if we come across anything else as we
gain experience on this platform.

Thanks for your help.

Bachman, William (MYD) wrote:
> In order to extend our body of knowledge of platforms used by our
> NONMEM users, we have investigated installation of NONMEM VI on a
> MacBook Pro. Much to our delight, it was a relatively easy
> experience. Essentially, we followed the Linux installation
> instructions given in Section III of the readme_6.1.0.doc found on the

> NONMEM VI installation CD-ROM with ONE notable exception. Despite the

> fact that the MacBook Pro uses an Intel Core 2 Duo processor, the IEEE

> machine constants were used and NOT the Intel machine constants
> (this can be done by not specifying an argument for the machine
> constants as IEEE is the default).
> The setup command used was:
> ./SETUP /opt/nmvi g95 '-O -fsloppy-char' /usr/bin/ar
> (This specifies an installation directory of /opt/nmvi, the g95
> compiler using the -O -fsloppy-char optimization options (enclosed in
> single quotes), the archive command path and, by default, the IEEE
> constants. The "./" before the command is required if your csh shell
> environment does not include the current directory, ".", in the PATH
> variable to execute any program in the current directory.)
> System Specifics:
> MacBook Pro 2,2
> Intel Core 2 Duo, 2.16 GHz
> 1 GB Memory
> Mac OS X 10.4.8 (Tiger)
> Installation and NONMEM runs done using the Mac Terminal Utility
> Required additional software:
> g95 Fortran compiler (g95-powerpc-osx.tar obtained from
> Xcode 2.4.1 Developers Tools (free from Apple)
> A particularly helpful website for high performance computing on the
> Mac (with respect to computation tools for the Mac) can be found at
>, ). This report represents preliminary
> results of our Mac investigations. Additional Mac-related information

> will be reported at a later date. Other NONMEM users have reported
> that the commercial Intel compiler is also a viable Fortran compiler
> for the Mac. Any additional Mac information that other nmusers would
> like to share will be greatly appreciated.
> William J. Bachman, Ph.D.
> Director, Pharmacometrics R&D
> Icon Development Solutions
> 6031 University Blvd., Suite 300
> Ellicott City, MD 21043
> Office 410-696-3002
> Cell 301-467-8635
> bachmanw
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Marc R. Gastonguay, Ph.D., President & CEO, Metrum Research Group LLC
2 Tunxis Rd. Suite 112, Tariffville, CT 06081
Direct:860-670-0744, Main:860-735-7043, Fax:860-760-6014

Received on Mon Mar 26 2007 - 14:32:13 EDT

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