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creating a data file for SS dosing

From: Varsha Mehta <varsham>
Date: Wed, 09 May 2007 14:27:44 -0400

Friends:


I am new to NONMEM. I am trying to create a data file for a drug that is =
dosed as follows.

Stress or loading dose Q 6hrs x 48 hours. Then maintenance dose is starte=
d as a Q 6h regimen 12 hours after the last loading dose. The plasma conc=
 is measured after 3-4 maintenance doses are administered.

I am trying to develop an excel data sheet as follows.

C ID AMT Time ADDL II DV Ht WT Age

Here for amount (AMT) how do I include the stress or LD information? Do =
I create a separate data line for these doses?
Any help is appreciated.

Varsha Mehta

Varsha Mehta, Pharm.D., FCCP
Clinical Associate Professor
Pharmacy, Pediatrics and Communicable Diseases
Clinical Pharmacist, Pediatric/Neonatal Critical Care
University of Michigan
(O) 734-936-8985
(F) 734-936-6946
varsham



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Received on Wed May 09 2007 - 14:27:44 EDT

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