NONMEM Users Network Archive

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Subpopulation

From: Huali Wu <hualiw>
Date: Tue, 12 Aug 2008 12:14:02 -0400

Dear NMusers:

I am trying to fit a dataset with 13 dose levels. The highest dose is =
about 10 times of the lowest dose. Each patient receive one dose and =
were sampled intensively up to 7 days. The results of individual PK =
analysis shown linear kinetics for some of the patients and nonlinear =
kinetics for the other patients. I have tried to fit all of them =
together. But my advisor wants me to fit linear patients and nonlinear =
patients separately to get a better look of fitting.

Additionally, all the nonlinear patients are from higher dose levels. =
But not all the patients in higher dose levels shown nonlinear kinetics. =
So my question is which way is more appropriate in this case? Should I =
fit them all together or separately? Could these two types of patients =
be considered as subpopulations?

Any comment or suggestion will be highly appreciated.

Best regards,

Huali


Received on Tue Aug 12 2008 - 12:14:02 EDT

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