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Re: NONMEM VI 2.0 Bug Alert #1

From: Nick Holford <n.holford>
Date: Wed, 20 Aug 2008 09:50:30 +1200

Wings for NONMEM (http://wfn.sourceforge.net) provides an updated
version of NMQUAL for installation of NONMEM for use with WFN
compilation version switching.

NMQ4WFN <http://wfn.sourceforge.net/NMQ4WFN-6.3.2.exe> version 6.3.2 is
compatible with NONMEM VI 2.0 (upto and including Bug Alert #1) and uses
NMQual 6.3.2 (thanks to Metrum Institute).

Ludden, Thomas wrote:
> Dear All:
>
> Below are listed three bugs that have been detected in NONMEM VI 2.0.
>
> The bug affecting PREDPP's TRANS6 is present in all versions starting
> with NONMEM V 1.0.
>
> The bug affecting NMTRAN's BIND is present in all versions starting
> with NONMEM IV 1.0.
>
> Fixed routines can be found at
> ftp://ftp.globomaxnm.com/Public/nonmem/NONMEM_VI_fixed_routines/ .
> Login is required to access this directory. The username is nonmemvi
> and the password is updates. The subdirectories PREDPP_15AUG2008 and
> NMTRAN_15AUG2008 contain the fixed TRANS6 and BIND routines, respectively.
>
> Tom
>
> ******************************************************************************
>
> NONMEM VI 2.0 Bug List
> ________________________________________________________
> nmfe6.bat
>
> 1. To prevent an extraneous character in the result file,
> locate in nmfe6.bat the command
>
> copy %2 +FMSG %2
>
> and change it to
>
> copy %2 +FMSG /b %2 /b
>
> _________________________________________________________
> PREDPP
>
> 1. There is a PREDPP bug in TRANS6 that affects the calculation of
> derivatives when used with
> ADVAN11 or ADVAN12. Simulations are unaffected. Estimation using a
> conditional method will
> yield a parameter search and results that are obviously problematic.
> Estimation using the FO
> method may or may not yield results that are obviously problematic.
>
> This bug is also present in all versions starting with NONMEM V 1.0
>
> This bug is not encountered when TRANS6 is used with ADVAN3 or ADVAN4.
>
> Fix:
> Locate in TRANS6 the line
>
> X +GG(1,1,1)*(K21*DK31+GG(4,KP,1)*K31))/(K21*K31)
>
> and replace with
>
> C CHANGED +GG(1,1,1) TO -GG(1,1,1) 6/2008
> X -GG(1,1,1)*(K21*DK31+GG(4,KP,1)*K31))/(K21*K31).
>
> _________________________________________________________
> NMTRAN
>
> 1. There is a bug in NMTRAN's BIND subroutine that is observed when
> the $BIND record is used,
> the date data item is dropped, and the label of the date data item in
> the $INPUT record is DAT1,
> DAT2, or DAT3.
>
> Processing of the control steam and data file are terminated with a
> spurious message from NMTRAN
> and there is no execution of NONMEM.
>
> The bug is present in all versions starting with NONMEM IV 1.0.
>
> Fix:
>
> Locate
> IF (DROPDT.AND.DNAME(I).EQ.'DATE') THEN
>
> Replace with
>
> C TEST FOR DAT1, DAT2, DAT3 ADDED 8/2008
> IF (DROPDT.AND.(DNAME(I).EQ.'DATE'
> X .OR.DNAME(I).EQ.'DAT1'.OR.DNAME(I).EQ.'DAT2'
> X .OR.DNAME(I).EQ.'DAT3')) THEN
> __________________________________________________________
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>

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Tue Aug 19 2008 - 17:50:30 EDT

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