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How to scale PARAMETERs

From: axel.facius
Date: Tue, 26 Aug 2008 18:44:47 +0200
Hi there!

During $ESTimation, NONMEM prints PARAMETER values. At ite= ration 0, these are all 'scaled' to 0.1. During long NONMEM runs I'm someti= mes interested in seeing where my current estimate of parameters are, so I = would like to re-scale them back. Unfortunately simple re-scalings like "pa= rameter" * 10 * "Initial-estimate" do not work (except for iteration 0 ;-).= If I do this for the parameters in the last iteration, I do not end up wit= h the final parameter estimates..?!

Does anybody know how to re-scal= e?

Cheers, Axel

Here some example:

initial est.: 0.4715E+00
i= nitial par.: 0.1000E+00
final par.: -0.5854E+00
final est.:
2.38E-01

taken from:


[...]
<= br style="font-family: Courier New,Courier,monospace;">0INITIAL ESTIMATE OF THETA:
 LOWER BOUND  &n= bsp; INITIAL EST    UPPER BOUND
  0.0000E+00     0.4715E+00&n= bsp;    0.1000E+07
[...]

 MO= NITORING OF SEARCH:

0ITERATION NO.: &n= bsp;  0    OBJECTIVE VALUE:  0.65915E+05 &nbs= p;  NO. OF FUNC. EVALS.:20
 CUMULATIVE NO. OF FUNC. EVALS.:   20
 PARAMETER:  0.1000E+00  .= .
 GRADIENT: &nb= sp; 0.1145E+06  ...

[...]

0ITERATION NO= .:   61    OBJECTIVE VALUE: -0.39051E+04 &nbs= p;  NO. OF FUNC. EVALS.:36
 CUMULATIVE NO. OF FUNC. EVALS.: 2195
 PARAMETER: -0.5854E+00  ...
 GRADIENT:   0.3601E+02&= nbsp; ...
<= span style="font-family: Courier New,Courier,monospace;">0MINIMIZATION SU= CCESSFUL


[...]<= br>
***************= ***************************************************************************= ******************************
 ********************       &n= bsp;            = ;            &n= bsp;            = ;            &n= bsp;            = ;          *******************= *
 ******************= **            &= nbsp;           &nbs= p;         FINAL PARAMETER ESTIMATE=             &nb= sp;         ********************

 ********************=             &nb= sp;            =             &nb= sp;            =             &nb= sp;            =      ********************
 *************************************************= ***********************************************************************



 = ;THETA - VECTOR OF FIXED EFFECTS PARAMETERS   *********

            TH= 1      ...

 =         2.38E-01    = ...




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Received on Tue Aug 26 2008 - 12:44:47 EDT

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