# RE: How to scale PARAMETERs

From: Bachman, William <William.Bachman>
Date: Tue, 26 Aug 2008 13:13:05 -0400

You can find the unscaled parameters at the iterations requested in the
PRINT= option of \$EST in the INTER file if you specify MSFO as an \$EST
option. The file exists only during the run (by default).

________________________________

From: owner-nmusers
On Behalf Of axel.facius
Sent: Tuesday, August 26, 2008 12:45 PM
To: nmusers
Subject: [NMusers] How to scale PARAMETERs

Hi there!

During \$ESTimation, NONMEM prints PARAMETER values. At iteration 0,
these are all 'scaled' to 0.1. During long NONMEM runs I'm sometimes
interested in seeing where my current estimate of parameters are, so I
would like to re-scale them back. Unfortunately simple re-scalings like
"parameter" * 10 * "Initial-estimate" do not work (except for iteration
0 ;-). If I do this for the parameters in the last iteration, I do not
end up with the final parameter estimates..?!

Does anybody know how to re-scale?

Cheers, Axel

Here some example:

initial est.: 0.4715E+00
initial par.: 0.1000E+00
final par.: -0.5854E+00
final est.: 2.38E-01

taken from:

[...]

0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.0000E+00 0.4715E+00 0.1000E+07
[...]

MONITORING OF SEARCH:

0ITERATION NO.: 0 OBJECTIVE VALUE: 0.65915E+05 NO. OF FUNC.
EVALS.:20
CUMULATIVE NO. OF FUNC. EVALS.: 20
PARAMETER: 0.1000E+00 ..

[...]

0ITERATION NO.: 61 OBJECTIVE VALUE: -0.39051E+04 NO. OF FUNC.
EVALS.:36
CUMULATIVE NO. OF FUNC. EVALS.: 2195
PARAMETER: -0.5854E+00 ...
0MINIMIZATION SUCCESSFUL

[...]

************************************************************************
************************************************
********************
********************
******************** FINAL PARAMETER
ESTIMATE ********************
********************
********************

************************************************************************
************************************************

THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********

TH 1 ...

2.38E-01 ...

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