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RE: NONMEM and g77

From: Michael Karol <MKarol>
Date: Wed, 27 Aug 2008 08:19:54 -0400

Hi All:

 

  Has anyone had similar problems with g77 on Windows XP? Is there a
better compiler for NONMEM?

 

Regards,

Michael

 

________________________________

From: owner-nmusers
On Behalf Of justin.wilkins
Sent: Tuesday, August 26, 2008 1:19 PM
To: nmusers
Subject: [NMusers] NONMEM and g77

 


Hi all,

We've run into some problems with NONMEM V and occasionally VI hanging
during minimization (the "black hole" phenomenon, in which NONMEM stops
iterating, but never terminates, indefinitely continuing to occupy 99%
of the CPU it's running on), using GNU g77 3.4.6 on Red Hat Linux - I
guess this is most likely related to g77's virtually non-existent
handling of floating point errors.

One way to address this would be to compile the trapfpe.c routine that's
floating around the Internet into the NONMEM library, I think, but I
can't help wondering whether there is a more elegant fix (apart from
writing less buggy NONMEM code).

Has anyone had any recent experience with dealing with this? If we were
to dump g77 altogether, what other compilers are known to work
adequately with NONMEM on Linux?

Best regards,
Justin

Justin Wilkins
Novartis Pharma AG
PH346, MODELING & SIMULATION
CHBS, WSJ-027.1.084
Novartis Pharma AG
Lichtstrasse 35
CH-4056 Basel
Switzerland
Phone: +41 61 324 6549
Fax: +41 61 324 3039
Mobile: +41 76 561 0949
Email : justin.wilkins


 


Received on Wed Aug 27 2008 - 08:19:54 EDT

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