NONMEM Users Network Archive

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Re: Code for EHC

From: Sam Liao <sliao>
Date: Thu, 04 Dec 2008 08:43:59 -0500

Dear Ayyappa:

I think you will find the following nmusers net post useful for your
model. Alison had kindly provided some code for a EHC model.

Best regards,
Sam Liao
Pharmax Research
===================================================================

*Enterohepatic Recirculation Model
<http://www.cognigencorp.com/nonmem/nm/98oct061998.html>*
    *|... |*this compartment to the change-point. Based on these ideas,
    here's how I would modify Rik's code. The change also provides for
    the termination of *EHC
    <http://www.cognigencorp.com/nonmem/nm/98oct061998.html#pgfId=424161>*.
    If you want to let *EHC* continue indefinitely, delete compartment 6
    and its dose, and the code involving ALAG6. 1) Add 2 more
    compartments to $MODEL:*| ...|*
    /http://www.cognigencorp.com/nonmem/nm/98oct061998.html/ 05/06/03,
    19876 bytes


>
> Dear All,
>
> I am trying to model PK data of a drug and many subjects show double
> peaks but even in fasting state. Can we expect EHC in fasting state?
> Can anybody provide some coding help in modeling intermittent
> episodes of EHC rather than continuous mode?
>
> Thank you.
>
>
> Regards,
> Ayyappa Chaturvedula
Received on Thu Dec 04 2008 - 08:43:59 EST

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