NONMEM Users Network Archive

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Simultaneous vs sequential for modeling parent AND metabolites in pop PK

From: Xiao, Alan <Alan.Xiao>
Date: Tue, 9 Dec 2008 11:02:08 -0500

Dear All,

I know this is an old topic but would like to see the statistics.

When you have to develop a pop PK model for both parent and active =
metabolites, which approach do you prefer or have you used most: =
simultaneous or sequential? Which way do you think is more scientific? I =
heard comments saying that the simultaneous approach is not scientific.

Thanks,

Alan
Received on Tue Dec 09 2008 - 11:02:08 EST

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