Dear All,
I know this is an old topic, too, but would like to see the statistics.
When you have a dataset with about 10% of dense Phase II data (predose, =
2, 4, 8, and 12 hrs post dose on day 1 and at steady state, twice-daily =
dose regimen) and about 90% of very sparse Phase III data (1-2 =
samples/patient), which method do you prefer: FO or FOCE? or FO for =
model development but FOCE for model refinement/finalization? If FOCE is =
not practical because of long run-time or numerical difficulties in =
converge, do you stop here or would you use FO?
Thanks,
Alan
Received on Tue Dec 09 2008 - 11:18:01 EST
