NONMEM Users Network Archive

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FO vs FOCE

From: Xiao, Alan <Alan.Xiao>
Date: Tue, 9 Dec 2008 11:18:01 -0500


Dear All,

I know this is an old topic, too, but would like to see the statistics.

When you have a dataset with about 10% of dense Phase II data (predose, =
2, 4, 8, and 12 hrs post dose on day 1 and at steady state, twice-daily =
dose regimen) and about 90% of very sparse Phase III data (1-2 =
samples/patient), which method do you prefer: FO or FOCE? or FO for =
model development but FOCE for model refinement/finalization? If FOCE is =
not practical because of long run-time or numerical difficulties in =
converge, do you stop here or would you use FO?


Thanks,

Alan
Received on Tue Dec 09 2008 - 11:18:01 EST

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