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RE: Simultaneous vs sequential for modeling parent AND metabolites in pop PK

From: Bachman, William <William.Bachman>
Date: Tue, 9 Dec 2008 11:25:52 -0500

The argument against the simultaneous approach is that the PD data can
"drive" the PK model, particulary since the PD data usually has more

-----Original Message-----
From: owner-nmusers
On Behalf Of Xiao, Alan
Sent: Tuesday, December 09, 2008 11:02 AM
To: nmusers
Subject: [NMusers] Simultaneous vs sequential for modeling parent AND
metabolites in pop PK

Dear All,

I know this is an old topic but would like to see the statistics.

When you have to develop a pop PK model for both parent and active
metabolites, which approach do you prefer or have you used most:
simultaneous or sequential? Which way do you think is more scientific? I
heard comments saying that the simultaneous approach is not scientific.


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Received on Tue Dec 09 2008 - 11:25:52 EST

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