NONMEM Users Network Archive

Hosted by Cognigen

RE: Simultaneous vs sequential for modeling parent AND metabolites in pop PK

From: Bachman, William <William.Bachman>
Date: Tue, 9 Dec 2008 11:25:52 -0500

The argument against the simultaneous approach is that the PD data can
"drive" the PK model, particulary since the PD data usually has more
variability.

-----Original Message-----
From: owner-nmusers
On Behalf Of Xiao, Alan
Sent: Tuesday, December 09, 2008 11:02 AM
To: nmusers
Subject: [NMusers] Simultaneous vs sequential for modeling parent AND
metabolites in pop PK

Dear All,

I know this is an old topic but would like to see the statistics.

When you have to develop a pop PK model for both parent and active
metabolites, which approach do you prefer or have you used most:
simultaneous or sequential? Which way do you think is more scientific? I
heard comments saying that the simultaneous approach is not scientific.

Thanks,

Alan
ICON plc made the following annotations.
-------------------------------------------------------------------------=
-----
This e-mail transmission may contain confidential or legally privileged i=
nformation
that is intended only for the individual or entity named in the e-mail ad=
dress. If you
are not the intended recipient, you are hereby notified that any disclosu=
re, copying,
distribution, or reliance upon the contents of this e-mail is strictly pr=
ohibited. If
you have received this e-mail transmission in error, please reply to the =
sender, so that
ICON plc can arrange for proper delivery, and then please delete the mess=
age.
Thank You,
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835

Received on Tue Dec 09 2008 - 11:25:52 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.