NONMEM Users Network Archive

Hosted by Cognigen

RE: Simultaneous vs sequential for modeling parent AND metabolites in pop PK

From: Hussein, Ziad <Ziad.Hussein>
Date: Tue, 9 Dec 2008 16:40:54 -0000

Hi Atul,

The emails must have crossed. However, this is not the FDA view based
on a recent experience where I have to repeat the analysis using the
simultaneous approach.

Kind regards,
Ziad
Dr Ziad Hussein
Senior Director, Pharmacometrics
ICON Development Solutions
Manchester
United Kingdom

-----Original Message-----
From: owner-nmusers
On Behalf Of Bhattaram, Atul
Sent: 09 December 2008 16:22
To: Xiao, Alan; nmusers
Subject: RE: [NMusers] Simultaneous vs sequential for modeling parent
AND metabolites in pop PK

Hello Alan

I have used a sequential approach in the past as the model was more
stable with lesser run time.

Atul


Venkatesh Atul Bhattaram
Pharmacometrics
Office of Clinical Pharmacology
US Food and Drug Administration


"The contents of this message are mine personally and do not necessarily
reflect any position of the Government or the Food and Drug
Administration."


-----Original Message-----
From: owner-nmusers
On Behalf Of Xiao, Alan
Sent: Tuesday, December 09, 2008 11:02 AM
To: nmusers
Subject: [NMusers] Simultaneous vs sequential for modeling parent AND
metabolites in pop PK

Dear All,

I know this is an old topic but would like to see the statistics.

When you have to develop a pop PK model for both parent and active
metabolites, which approach do you prefer or have you used most:
simultaneous or sequential? Which way do you think is more scientific? I
heard comments saying that the simultaneous approach is not scientific.

Thanks,

Alan
ICON plc made the following annotations.
-------------------------------------------------------------------------=
-----
This e-mail transmission may contain confidential or legally privileged i=
nformation
that is intended only for the individual or entity named in the e-mail ad=
dress. If you
are not the intended recipient, you are hereby notified that any disclosu=
re, copying,
distribution, or reliance upon the contents of this e-mail is strictly pr=
ohibited. If
you have received this e-mail transmission in error, please reply to the =
sender, so that
ICON plc can arrange for proper delivery, and then please delete the mess=
age.
Thank You,
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835

Received on Tue Dec 09 2008 - 11:40:54 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.