NONMEM Users Network Archive

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Re: ETA on ALAG1

From: Nick Holford <n.holford>
Date: Sat, 13 Dec 2008 10:13:37 +1300


It is not an error to have a negative objective function value.

It is an error not to describe the problem accurately.

If you want to get help from nmusers then please quote the EXACT wording
of the error message and describe what you did that caused the error to


> Dear All,
> It is an old topic, but definetely not completely resolved. Can
> anybody provide tips on estimating variability on ALAG1 in a 2 comp,
> oral absorption model (I am using NONMEM V). I am getting an error
> message OBJFUN is negative. I have searched in usernet archive but
> could not solve the problem. I appreciate your help.
> Regards,
> Ayyappa Chaturvedula
> GlaxoSmithKline
> 1500 Littleton Road,
> Parsippany, NJ 07054
> Ph:9738892200

Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
Received on Fri Dec 12 2008 - 16:13:37 EST

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