NONMEM Users Network Archive

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Re: ETA on ALAG1

From: nidal.alhuniti
Date: Fri, 12 Dec 2008 16:50:05 -0500

As Nick said you could have a negative objective function that is not an
error. Usually estimating an ETA on lag time could be problematic; however
you could use the hybrid method in NM. Please see the NM help files for more

*Nidal AL-Huniti, PhD*

*Associate Director, Modeling and Simulations *

*ICON Development Solutions *

On 12/12/08, Nick Holford <n.holford
> Ayyappa,
> It is not an error to have a negative objective function value.
> It is an error not to describe the problem accurately.
> If you want to get help from nmusers then please quote the EXACT wording of
> the error message and describe what you did that caused the error to appear.
> Nick
> ayyappa.5.chaturvedula
>> Dear All,
>> It is an old topic, but definetely not completely resolved. Can anybody
>> provide tips on estimating variability on ALAG1 in a 2 comp, oral absorption
>> model (I am using NONMEM V). I am getting an error message OBJFUN is
>> negative. I have searched in usernet archive but could not solve the
>> problem. I appreciate your help.
>> Regards,
>> Ayyappa Chaturvedula
>> GlaxoSmithKline
>> 1500 Littleton Road,
>> Parsippany, NJ 07054
>> Ph:9738892200
> --
> Nick Holford, Dept Pharmacology & Clinical Pharmacology
> University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
> Zealand
> n.holford

Received on Fri Dec 12 2008 - 16:50:05 EST

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