NONMEM Users Network Archive

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RE: ETA on ALAG1

From: Samtani, Mahesh [PRDUS] <MSamtani>
Date: Fri, 12 Dec 2008 16:57:33 -0500

Hello,
The easy fix is to use the Hybrid option. See this posting: =
<http://www.cognigencorp.com/nonmem/nm/99jun022003.html> =
http://www.cognigencorp.com/nonmem/nm/99jun022003.html The key messages =
are at the very end of this thread:
        "....you might try the hybrid method specifying that the eta for =
tlag is approximated by FO while the others use FOCE. See NONMEM Guide =
VII, pp 14-15."
        "....Thanks for the suggestion, you have no idea how much my day =
gets improved by a MINIMIZATION SUCCESSFUL."
 
The more elegant solution (but will take time due to the use of $DES) is =
to use the transit compartment absorption model. You can look up Dr. =
Savic's or Dr. Wilkin's presentation on the PAGE website or see Dr. =
Savic's paper.
         <http://www.page-meeting.org/?abstract=513> =
http://www.page-meeting.org/?abstract=513
         <http://www.page-meeting.org/?abstract=1113> =
http://www.page-meeting.org/?abstract=1113
        http://www.springerlink.com/content/wm7763462310778q/
 
Good luck,
Mahesh

-----Original Message-----
From: owner-nmusers
[mailto:owner-nmusers
ayyappa.5.chaturvedula
Sent: Friday, December 12, 2008 4:00 PM
To: nmusers
Subject: [NMusers] ETA on ALAG1



Dear All,

It is an old topic, but definetely not completely resolved. Can anybody =
provide tips on estimating variability on ALAG1 in a 2 comp, oral =
absorption model (I am using NONMEM V). I am getting an error message =
OBJFUN is negative. I have searched in usernet archive but could not =
solve the problem. I appreciate your help.

Regards,
Ayyappa Chaturvedula
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200


Received on Fri Dec 12 2008 - 16:57:33 EST

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