NONMEM Users Network Archive

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RE: ETA on ALAG1

From: Mouksassi Mohamad-Samer <mohamad-samer.mouksassi>
Date: Fri, 12 Dec 2008 18:08:49 -0500

Dear Ayyappa,

You may find the following link useful it suggests that a mixture model =
may be helpful to estimate ETAS:

Estimating Variability of Infusion Rate or Duration and Lag Time Using =
Mixture Models
J. Ahn, T. Ludden
http://www.aapsj.org/abstracts/AM_2007/AAPS2007-000939.PDF

Bests,

Samer



-----Original Message-----
From: owner-nmusers
ayyappa.5.chaturvedula
Sent: Fri 12/12/2008 16:00
To: nmusers
Subject: [NMusers] ETA on ALAG1
 
Dear All,

It is an old topic, but definetely not completely resolved. Can anybody =

provide tips on estimating variability on ALAG1 in a 2 comp, oral
absorption model (I am using NONMEM V). I am getting an error message
OBJFUN is negative. I have searched in usernet archive but could not
solve the problem. I appreciate your help.

Regards,
Ayyappa Chaturvedula
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200
Received on Fri Dec 12 2008 - 18:08:49 EST

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