NONMEM Users Network Archive

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Michaelis-Menten model

From: nonmem
Date: Sat, 12 Jul 2008 12:35:08 +0000 (GMT)

Hello NONMEM users,

The classic Michaelis-Menton model predicts the same terminal slopes for different doses. I tried to use indirect response models to account for different slopes, but it was not fruitful. Can you recomend a set of empirical or mecanistic models, which predict very different terminel slopes at different doses?

Thanks!
Pavel

Received on Sat Jul 12 2008 - 08:35:08 EDT

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