NONMEM Users Network Archive

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Re: Michaelis-Menten model

From: Nick Holford <n.holford>
Date: Sat, 12 Jul 2008 12:59:16 -0400

Pavel,

You dont give any background to help answer this question. But if the
doses have different first-order absorption rates and the absorpion
half-life is slower than the elimination half-life (flip-flop) then you
may see dose dependent terminal half-lives.

Nick

nonmem
> Hello NONMEM users,
>
> The classic Michaelis-Menton model predicts the same terminal slopes
> for different doses. I tried to use indirect response models to
> account for different slopes, but it was not fruitful. Can you
> recomend a set of empirical or mecanistic models, which predict very
> different terminel slopes at different doses?
>
> Thanks!
> Pavel

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Sat Jul 12 2008 - 12:59:16 EDT

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