NONMEM Users Network Archive

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Re: Michaelis-Menten model

From: nonmem
Date: Wed, 16 Jul 2008 01:03:10 +0000 (GMT)

Thank you Zaid. After 101 atempts, I did it. One of the indirect-response models worked. There was a dose-dependent inhibition of elimination.

----- Original Message -----
From: Hussein, Ziad
Date: Saturday, July 12, 2008 9:22 am
Subject: Re: [NMusers] Michaelis-Menten model
To: nonmem

> How about modelling the effect of dose on the terminal slope
> starting with a full exponential model with an intercept and
> reduce it further if some of the parameters are poorly estimated?
> Best of luck.
> Dr Ziad Hussein
> ICON Development Solutions
> ----- Original Message -----
> From: owner-nmusers
> To: nmusers
> Sent: Sat Jul 12 13:35:08 2008
> Subject: [NMusers] Michaelis-Menten model
> Hello NONMEM users,
> The classic Michaelis-Menton model predicts the same terminal
> slopes for different doses. I tried to use indirect response
> models to account for different slopes, but it was not fruitful.
> Can you recomend a set of empirical or mecanistic models, which
> predict very different terminel slopes at different doses?
> Thanks!
> Pavel
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Received on Tue Jul 15 2008 - 21:03:10 EDT

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