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RE: Combined absorption model

From: Howard Lee <leehwd>
Date: Mon, 21 Jul 2008 09:31:52 -0400

Dear Galadriel,

When the RATE data item is coded "-2", then you should estimate D2 (duration
for the central compartment), instead of R2.

Howard Lee

-----Original Message-----
From: owner-nmusers
Behalf Of Galadriel
Sent: Monday, July 21, 2008 5:08 AM
To: nmusers
Subject: [NMusers] Combined absorption model

Dear all,

I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx-pop library,

...........
CL=THETA(1)*EXP(ETA(1))
V2=THETA(2)*EXP(ETA(2))
Q =THETA(3)*EXP(ETA(3))
V3=THETA(4)*EXP(ETA(4))
KA=THETA(5)*EXP(ETA(5))
R2=THETA(6)*EXP(ETA(6))
F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
F2=1-F1
S2=V2
.................

and for each dose record, an additional IV adminstration dose record
is inserted with same dosage & rate=-2

ID TIME AMT DV CMT RATE........
1 0 100 . 1 0 .........
1 0 100 . 2 -2 .........

An error message is reported 'PK PARAMETER FOR DURATION IS NOT
SUPPLIED BY PK FOR COMPT. NO. 2'.

So is it the proper way to code the data? How can I estimate combined
absorption model without using the differiential equation?

Many thanks for your help!

BR,
Galadriel
Received on Mon Jul 21 2008 - 09:31:52 EDT

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