From: Howard Lee <*leehwd*>

Date: Mon, 21 Jul 2008 09:31:52 -0400

Dear Galadriel,

When the RATE data item is coded "-2", then you should estimate D2 (duration

for the central compartment), instead of R2.

Howard Lee

-----Original Message-----

From: owner-nmusers

Behalf Of Galadriel

Sent: Monday, July 21, 2008 5:08 AM

To: nmusers

Subject: [NMusers] Combined absorption model

Dear all,

I tried to build up a combined absorption model (zero order + first

order)using ADVAN 4, following is the control file I found in the

PDx-pop library,

...........

CL=THETA(1)*EXP(ETA(1))

V2=THETA(2)*EXP(ETA(2))

Q =THETA(3)*EXP(ETA(3))

V3=THETA(4)*EXP(ETA(4))

KA=THETA(5)*EXP(ETA(5))

R2=THETA(6)*EXP(ETA(6))

F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))

F2=1-F1

S2=V2

.................

and for each dose record, an additional IV adminstration dose record

is inserted with same dosage & rate=-2

ID TIME AMT DV CMT RATE........

1 0 100 . 1 0 .........

1 0 100 . 2 -2 .........

An error message is reported 'PK PARAMETER FOR DURATION IS NOT

SUPPLIED BY PK FOR COMPT. NO. 2'.

So is it the proper way to code the data? How can I estimate combined

absorption model without using the differiential equation?

Many thanks for your help!

BR,

Galadriel

Received on Mon Jul 21 2008 - 09:31:52 EDT

Date: Mon, 21 Jul 2008 09:31:52 -0400

Dear Galadriel,

When the RATE data item is coded "-2", then you should estimate D2 (duration

for the central compartment), instead of R2.

Howard Lee

-----Original Message-----

From: owner-nmusers

Behalf Of Galadriel

Sent: Monday, July 21, 2008 5:08 AM

To: nmusers

Subject: [NMusers] Combined absorption model

Dear all,

I tried to build up a combined absorption model (zero order + first

order)using ADVAN 4, following is the control file I found in the

PDx-pop library,

...........

CL=THETA(1)*EXP(ETA(1))

V2=THETA(2)*EXP(ETA(2))

Q =THETA(3)*EXP(ETA(3))

V3=THETA(4)*EXP(ETA(4))

KA=THETA(5)*EXP(ETA(5))

R2=THETA(6)*EXP(ETA(6))

F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))

F2=1-F1

S2=V2

.................

and for each dose record, an additional IV adminstration dose record

is inserted with same dosage & rate=-2

ID TIME AMT DV CMT RATE........

1 0 100 . 1 0 .........

1 0 100 . 2 -2 .........

An error message is reported 'PK PARAMETER FOR DURATION IS NOT

SUPPLIED BY PK FOR COMPT. NO. 2'.

So is it the proper way to code the data? How can I estimate combined

absorption model without using the differiential equation?

Many thanks for your help!

BR,

Galadriel

Received on Mon Jul 21 2008 - 09:31:52 EDT