From: Sam Liao <*sliao*>

Date: Mon, 21 Jul 2008 09:58:15 -0400

Dear Galadriel:

You would need to provide an estimate of D2, the duration of zero-order

input to CMT=2 in your model.

Sam Liao

Pharmax Research

*> Dear all,
*

*>
*

*> I tried to build up a combined absorption model (zero order + first
*

*> order)using ADVAN 4, following is the control file I found in the
*

*> PDx-pop library,
*

*>
*

*> ...........
*

*> CL=THETA(1)*EXP(ETA(1))
*

*> V2=THETA(2)*EXP(ETA(2))
*

*> Q =THETA(3)*EXP(ETA(3))
*

*> V3=THETA(4)*EXP(ETA(4))
*

*> KA=THETA(5)*EXP(ETA(5))
*

*> R2=THETA(6)*EXP(ETA(6))
*

*> F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
*

*> F2=1-F1
*

*> S2=V2
*

*> .................
*

*>
*

*> and for each dose record, an additional IV adminstration dose record
*

*> is inserted with same dosage & rate=-2
*

*>
*

*> ID TIME AMT DV CMT RATE........
*

*> 1 0 100 . 1 0 .........
*

*> 1 0 100 . 2 -2 .........
*

*>
*

*> An error message is reported 'PK PARAMETER FOR DURATION IS NOT
*

*> SUPPLIED BY PK FOR COMPT. NO. 2'.
*

*>
*

*> So is it the proper way to code the data? How can I estimate combined
*

*> absorption model without using the differiential equation?
*

*>
*

*> Many thanks for your help!
*

*>
*

*> BR,
*

*> Galadriel
*

*>
*

*>
*

*>
*

*>
*

Received on Mon Jul 21 2008 - 09:58:15 EDT

Date: Mon, 21 Jul 2008 09:58:15 -0400

Dear Galadriel:

You would need to provide an estimate of D2, the duration of zero-order

input to CMT=2 in your model.

Sam Liao

Pharmax Research

Received on Mon Jul 21 2008 - 09:58:15 EDT