NONMEM Users Network Archive

Hosted by Cognigen

RE: How to code vomit event as absorption lag and lost of amount in administration comp.

From: Willavize, Susan A <susan.a.willavize>
Date: Tue, 22 Jul 2008 08:37:21 -0400

Hi Gabriel,

Is it possible that you do not need a PK model? Can you use a
"nonparametric" (connect the dots) approach for the PK and just use that
to drive the PD model? Just a thought.

Susan Willavize, Ph.D.
Pfizer Global Pharmacometrics Group

-----Original Message-----
From: owner-nmusers
On Behalf Of Galadriel
Sent: Tuesday, July 22, 2008 7:13 AM
To: nmusers
Subject: [NMusers] How to code vomit event as absorption lag and lost of
amount in administration comp.

Dear all,

Could someone please give me some tips coding vomitting event as an
absorption lag and bioavailability decrease?

It's a single dose oral solution with slow absorption. From data I
noticed that the time of vomitting was at least 4 hour after dose.
Some subjects had mutiple vomitting events. The exposure was noticed a
delay after each vomitting compared with non-vomit subject.

I have very limit data, and need a good fiitting for the plasma
concentration to focus on the pd model. Is there any similar model
reported in the literature?

Much appreciate for your help!

Best regards,
Galadriel
Received on Tue Jul 22 2008 - 08:37:21 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.