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RE: How to code vomit event as absorption lag and lost of amount in administration comp.

From: Mark Sale - Next Level Solutions <mark>
Date: Tue, 22 Jul 2008 06:42:00 -0700
Galadriel,
  could you turn the dose compartment off with an oth= er event (EVID = 2, CMT = -1), then given another dose after that. = ; E.G, with emesis at four hours:
#ID  TIME CMT AMT EVID  IND&= nbsp;
1     0      &n= bsp; 1    100   1     &nb= sp; 1
1     4      -1  &nbs= p;   .     2        0 1     4        1  &= nbsp; 100   1       2


$PK
 = ; IF(IND.EQ.1) THEN
    F1 = THETA(1)  ; FRACTION = NOT LOST
   ALAG1 = THETA(2)  ; NORMAL LAG
  EL= SE
    F1 = (1-THETA(1))*THETA(3) ; THETA(3) IS REDUCED= BIOAVAILABILITY
   ALAG1 = THETA(4) ; LAG AFTER EMESIS
&= nbsp; END IF


 Other-Type Event:
     A p= ositive value of CMT specifies a compartment to be turned on.
  &n= bsp;  A negative value of CMT specifies a compartment to be turned off= .
     When CMT is 0, no change is made in the status &n= bsp;of  any  compart-
     ment.
  &n= bsp;  PCMT is the same as for dose events.

Mark (aka Golum)

Mark Sale MD 
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185

-------- Original Message --------
Subject: [NMusers] How to code vomit event as absorption lag and lost
of amount in administration comp.
From: Galadriel <wyxiong Date: Tue, July 22, 2008 7:13 am
To:
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left.letterhead)

Received on Tue Jul 22 2008 - 09:42:00 EDT

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