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RE: How to code vomit event as absorption lag and lost of amountin administration comp.

From: Mark Sale - Next Level Solutions <mark>
Date: Tue, 22 Jul 2008 07:06:18 -0700
Let me revise that, the previous would give the same fraction as lost fo= r any time point after dosing
#ID TIME AMT CMT EVID IND
1  =    0      100    1 &= nbsp;  1     1
1     4 = ;       .     -1 &nb= sp;  2     0
1     4 &= nbsp;    100    1    1 &n= bsp;   2

$PK 
  IF(IND.EQ.1) THEN
 &= nbsp;  F1 = 1 ; DON'T NEED TO CHANGE THIS, AMT AFTER EMESIS WILL VAN= ISH WITH CMT = -1
   ALAG1 = THETA(1)
  ELSE
&n= bsp;   F1 = EXP(TIME*(-KA))*THETA(2) ; EXP(TIME*(-KA)) SHOULD B= E FRACTION REMAINING AT
             =                     &nbs= p;               ; TIME =4, THEN SOME = FRACTION OF THIS (THETA(2)
   ALAG1 = THETA(3)
  END= IF

I think this will put the full amount into CMT 1 at T=0, then = have it vanish at T=4 (effectively reducing F1), then put the remaining f= raction (EXP((TIME*(-KA))) back, put only some estimate fraction of it (THE= TA(2), and give it some different lag time - I think.  I think it coul= d be adapted easily enough for multiple emesis events.


Alternati= vely, you could put the doses into seperate compartments, but this will get= cumbesome if you have multiple emesis events.

Mark

Mark Sal= e MD
Next Level Solutions, LLC
www.Next= LevelSolns.com
919-846-9185

---= ----- Original Message --------
Subject: [NMusers] How to code vomit ev= ent as absorption lag and lost
of amount in administration comp.
Fr= om: Galadriel <wyxiong m
To:
(image/png attachment:
left.letterhead)

Received on Tue Jul 22 2008 - 10:06:18 EDT

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