# RE: How to code vomit event as absorption lag and lost of amountin administration comp.

From: Mark Sale - Next Level Solutions <mark>
Date: Tue, 22 Jul 2008 07:06:18 -0700 Let me revise that, the previous would give the same fraction as lost fo= r any time point after dosing#ID TIME AMT CMT EVID IND1  =    0      100    1 &= nbsp;  1     11     4 = ;       .     -1 &nb= sp;  2     01     4 &= nbsp;    100    1    1 &n= bsp;   2\$PK    IF(IND.EQ.1) THEN &= nbsp;  F1 = 1 ; DON'T NEED TO CHANGE THIS, AMT AFTER EMESIS WILL VAN= ISH WITH CMT = -1   ALAG1 = THETA(1)  ELSE&n= bsp;   F1 = EXP(TIME*(-KA))*THETA(2) ; EXP(TIME*(-KA)) SHOULD B= E FRACTION REMAINING AT             =                     &nbs= p;               ; TIME =4, THEN SOME = FRACTION OF THIS (THETA(2)   ALAG1 = THETA(3)  END= IFI think this will put the full amount into CMT 1 at T=0, then = have it vanish at T=4 (effectively reducing F1), then put the remaining f= raction (EXP((TIME*(-KA))) back, put only some estimate fraction of it (THE= TA(2), and give it some different lag time - I think.  I think it coul= d be adapted easily enough for multiple emesis events.Alternati= vely, you could put the doses into seperate compartments, but this will get= cumbesome if you have multiple emesis events.Mark Mark Sal= e MD Next Level Solutions, LLC www.Next= LevelSolns.com 919-846-9185 ---= ----- Original Message -------- Subject: [NMusers] How to code vomit ev= ent as absorption lag and lost of amount in administration comp. Fr= om: Galadriel