NONMEM Users Network Archive

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RE: Joint model fitting to data on separate enantiomers and enantiomeric mixtures

From: Martin Bergstrand <martin.bergstrand>
Date: Tue, 24 Jun 2008 11:11:21 +0200


Dear Johan and Anna,

I answered to a similar question about a year ago. You can find that thread
via this link:
http://www.cognigencorp.com/nonmem/current/2007-July/0282.html.

Kind regards,
Martin


-----Original Message-----
From: owner-nmusers
Behalf Of Rosenborg, Johan
Sent: den 18 juni 2008 16:28
To: nmusers
Cc: Johansson, Anna X
Subject: [NMusers] Joint model fitting to data on separate enantiomers and
enantiomeric mixtures

All,

We have a data set comprising three measurements per time point, namely the
separate R- and S-concentrations and the total concentration (R+S) of a
chiral drug given as the racemic mixture. We would like to fit a model to
all data simultaneously. The plan is to estimate one set of parameters for
the S- enantiomer and one set for the R- enantiomer, using the sum of S- and
R concentrations to predict R+S; defining CMTs 1, 3, and 5 as observational
compartments for R-, S-, and RS, respectively, we would like to model
A(5)=A(1)+A(3). Any suggestion on how to do proceed with this in ADVAN5 or
ADVAN6 would be appreciated!

/ Johan and Anna
Received on Tue Jun 24 2008 - 05:11:21 EDT

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