NONMEM Users Network Archive

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Re: iNTRAVENOUS VS. INTRA-ARTERIAL SAMPLING

From: Murad Melhem <melhemmr>
Date: Mon, 30 Jun 2008 12:09:14 -0400

Hi Michael,

I think this reference may be useful in answering your question:

Darwish M, Kirby M, Robertson P Jr, Hellriegel E, Jiang JG. Comparison of
equivalent doses of fentanyl buccal tablets and arteriovenous differences in
fentanyl pharmacokinetics. Clin Pharmacokinet. 2006;45(8):843-50.

Regards,

*Murad Melhem, PhD*
*Assistant Director PK/PD*
*Cognigen Corporation*

On Mon, Jun 30, 2008 at 10:31 AM, <Michael.J.Fossler

>
> Hi everyone;
>
> Does anyone have experience modeling data where some samples were drawn
> intravenously, while others (sometimes even within a given patient) were
> drawn from an arterial line? There are no samples drawn simultaneously from
> both lines, unfortunately.
>

Received on Mon Jun 30 2008 - 12:09:14 EDT

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