NONMEM Users Network Archive

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Re: iNTRAVENOUS VS. INTRA-ARTERIAL SAMPLING

From: Sébastien Bihorel <sbihorel>
Date: Mon, 30 Jun 2008 13:16:54 -0400

Hi Michael,

You may also look at these references

*1.* Tuk B, van Gool T, Danhof M. Mechanism-based
pharmacodynamic modeling of the interaction of midazolam, bretazenil,
and zolpidem with ethanol. /J Pharmacokinet Pharmacodyn. /Jun
2002;29(3):235-250.

*2.* Tuk B, Danhof M, Mandema JW. The impact of arteriovenous
concentration differences on pharmacodynamic parameter estimates. /J
Pharmacokinet Biopharm. /Feb 1997;25(1):39-62.

Sebastien

Michael.J.Fossler
>
> Hi everyone;
>
> Does anyone have experience modeling data where some samples were
> drawn intravenously, while others (sometimes even within a given
> patient) were drawn from an arterial line? There are no samples drawn
> simultaneously from both lines, unfortunately.

Received on Mon Jun 30 2008 - 13:16:54 EDT

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