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Re: Pharmacokinetics is what the body does to the drug ...

From: Nick Holford <n.holford>
Date: Sun, 09 Nov 2008 09:42:06 +1300

Thanks to all those who responded. Here is the winner:

wjjusko
> Hi Nick:
> I believe Les Benet first made public pronunciation
> of these famous words.
> Bill
I asked Les Benet for his recollections and received this:

"I did a little more searching. I do think that I was the first to
publish those definitions, and I have now found it in two of my chapter
publications in 1984.

However, the most relevant is my single authored Chapter entitled,
"Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug
Metabolism", which begins "Pharmacokinetics may be simply defined as
what the body does to the drug, as opposed to pharmacodynamics which may
be defined as what the drug does to the body" p 199 in Drug Metabolism
and Drug Toxicity, JR Mitchell and MG Horning eds., Raven Press, New
York, 1984.

This is the most relevant because the book resulted from an ASPET
Workshop titled the same as the book that was held October 9-12, 1980 in
Houston. My talk was on October 9. By the way, I keep a record of the
titles of all the slides that I present. I see no prior reference to
that definition of pharmacokinetics before that talk. And at least for
me, I can really pinpoint that the definition above was created in early
October 1980, because on October 2 at the First North American
Conference on the Effects of Disease States on Clinical Pharmacokinetics
in Vancouver, BC, my slide used the more conventional definition of
pharmacokinetics, "Pharmacokinetics is the study of the kinetics of
absorption, distribution, metabolism and excretion of drugs, and their
corresponding pharmacologic, therapeutic and toxic response in man and
animals."

I think the we should recognize this as another of the many
contributions Les Benet has made to PKPD. The original phrase is:

 "Pharmacokinetics may be simply defined as what the body does to the
drug, as opposed to pharmacodynamics which may be defined as what the
drug does to the body"

and the official reference:

Benet LZ, "Pharmacokinetics: Basic Principles and Its Use as a Tool in
Drug Metabolism", p 199 in Drug Metabolism and Drug Toxicity, JR
Mitchell and MG Horning eds., Raven Press, New York, 1984.

The book is partially available on Google Books.
http://books.google.co.nz/books?lr=&ei=7fcVSZ-dD43gtgPA8d2DDA&id=Pf5sAAAAMAAJ&dq=Drug+Metabolism+and+Drug+Toxicity%2C+JR+Mitchell+and+MG+Horning+eds.%2C+Raven+Press%2C+New+York%2C+1984.&q=benet&pgis=1

But unfortunately it seems that the chapter written by Les has not been
digitized.

Drug Metabolism and Drug Toxicity: [based on Workshop on Drug Metabolism
and Drug Toxicity held Oct. 1980, at the Baylor College of Medicine]
By Jerry R. Mitchell, Marjorie G. Horning, American Society for
Pharmacology and Experimental Therapeutics
Published by Raven Press, 1984
Original from the University of Michigan
Digitized 19 Aug 2008
ISBN 0890049971, 9780890049976
436 pages


If, by chance, someone can document an earlier use of the phrase then
please let me know.

Best wishes,

Nick

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford


Received on Sat Nov 08 2008 - 15:42:06 EST

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