NONMEM Users Network Archive

Hosted by Cognigen

RE: Use of ADDL and II

From: Brian M. Sadler <bsadler1>
Date: Wed, 12 Nov 2008 11:48:09 -0500

Batul,

 

With the addition of an EVID variable, both methods should work. If you can
assume that the system is at steady-state, it may be more efficient to use
the SS data item rather than individual doses to bring the system up to the
point of the first sample.

 

Cheers. Brian

 

Brian M. Sadler, Ph.D.

Strategic PK Consulting, LLC

1209 Seabrook Avenue

Cary, North Carolina 27511

USA

 <mailto:bsadler1

+1 (919) 523-5485 (mobile)

+1 (508) 408-0250 (fax)

 

 

 

From: owner-nmusers
Behalf Of Batul Parta
Sent: Wednesday, November 12, 2008 10:36 AM
To: nmusers
Subject: [NMusers] Use of ADDL and II

 


Dear All,

I am modeling a repeated dosing study. Subjects were given twice daily doses
for 8 weeks and a number of samples were taken on the last day of dosing.
There were also sparse samples taken at weeks 2, 4, and 6. I want to use
ADDL and II for the dosing scheme. Can I lump all doses into one line or do
I have to stop the dosing record prior to each sample and re-start again? In
other words, will the following file structure work:

ID TIME AMT ADDL II DV
1 0 10 112 12 0
1 143 0 0 0 124
1 287 0 0 0 131
.
.
.

Or do I have to use the following:

ID TIME AMT ADDL II DV
1 0 10 14 12 0
1 143 0 0 0 124
1 144 10 14 12 0
1 287 0 0 0 131
.
.
.

Thank you in advance.

BP



 



Received on Wed Nov 12 2008 - 11:48:09 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.