NONMEM Users Network Archive

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RE: Very small P-Value for ETABAR

From: Denney, William S. <william_denney>
Date: Thu, 13 Nov 2008 10:41:15 -0500

Hi Jian,
 
I would look for a covariate effect on that parameter.
 
Thanks,
 
Bill

________________________________

From: owner-nmusers
On Behalf Of Jian Xu
Sent: Thursday, November 13, 2008 10:16 AM
To: nmusers
Subject: [NMusers] Very small P-Value for ETABAR


Dear NMUSERS,
 
A few years back, there was a discussion on the P-value for ETABAR.
However, I am not sure how to appropriately handle very small P-value(s)
for ETABAR situation during the development of a model.
 
I need some clarifications to a few questions:
1: Should we just ignore this small P-Value warning?
2: Can we change IIV model to avoid small P-value for ETABAR? Or any
other suggestions?
3: Does NONMEM make any assumptions on ETA distribution?
 
This P-value for ETABAR really bugs me a lot. I look forward to seeing
some input.
 
Thank you and I appreicate your time and help.
 
Jian

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Received on Thu Nov 13 2008 - 10:41:15 EST

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