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RE: Very small P-Value for ETABAR

From: Gupta, Pankaj <Pankaj.Gupta>
Date: Thu, 13 Nov 2008 11:13:53 -0500

You might want to look at the shrinkage for the eta in question.






From: owner-nmusers
On Behalf Of Denney, William S.
Sent: Thursday, November 13, 2008 10:41 AM
To: Jian Xu; nmusers
Subject: RE: [NMusers] Very small P-Value for ETABAR


Hi Jian,


I would look for a covariate effect on that parameter.







From: owner-nmusers
On Behalf Of Jian Xu
Sent: Thursday, November 13, 2008 10:16 AM
To: nmusers
Subject: [NMusers] Very small P-Value for ETABAR



A few years back, there was a discussion on the P-value for ETABAR.
However, I am not sure how to appropriately handle very small P-value(s)
for ETABAR situation during the development of a model.


I need some clarifications to a few questions:

1: Should we just ignore this small P-Value warning?

2: Can we change IIV model to avoid small P-value for ETABAR? Or any
other suggestions?

3: Does NONMEM make any assumptions on ETA distribution?


This P-value for ETABAR really bugs me a lot. I look forward to seeing
some input.


Thank you and I appreicate your time and help.




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Received on Thu Nov 13 2008 - 11:13:53 EST

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