From: Susan Zhou <*susan.zhou*>

Date: Thu, 20 Nov 2008 22:18:12 -0500

Hi, Everybody,

I have used Andrew Hooker's code to calculate CWRES with NONMEM 6.1

before (the NONMEM verbatim code and the R code for calculation). Now

our NONMEM has been upgraded to 6.2, and I am having problems with the

calculation of CWRES using the same code. In my NONMEM code, for the

error structure I used the following code for the combined error model

$SIGMA

1 FIXED

...

$PK

...

PERR=THETA(5)

AERR=THETA(6)

...

$ERROR

Y=F+(F*PERR + AERR)*EPS(1)

with NONMEM 6.1 and 6.2 using the exact same control file (with the

verbatim code for generating the matrices used for CWRES calculation

included), the outputs of the matrices are different. When using NONMEM

6.1, the output sigma and sesigma matrices used for calculation of CWRES

are non zero, and the NONMEM 6.2 outputs for these matrices are zero

matrices. The zero matrices seems to be one of the problems in

calculation of CWRES.

I saw in one thread that Tom Ludden mentioned that NONMEM 6.2 can output

the matrices used for calculation of CWRES directly in table format

without using the verbatim code. Has anybody used that function in 6.2

and would be willing to share the code.

Any help would be much appreciated.

Regards,

Susan

Received on Thu Nov 20 2008 - 22:18:12 EST

Date: Thu, 20 Nov 2008 22:18:12 -0500

Hi, Everybody,

I have used Andrew Hooker's code to calculate CWRES with NONMEM 6.1

before (the NONMEM verbatim code and the R code for calculation). Now

our NONMEM has been upgraded to 6.2, and I am having problems with the

calculation of CWRES using the same code. In my NONMEM code, for the

error structure I used the following code for the combined error model

$SIGMA

1 FIXED

...

$PK

...

PERR=THETA(5)

AERR=THETA(6)

...

$ERROR

Y=F+(F*PERR + AERR)*EPS(1)

with NONMEM 6.1 and 6.2 using the exact same control file (with the

verbatim code for generating the matrices used for CWRES calculation

included), the outputs of the matrices are different. When using NONMEM

6.1, the output sigma and sesigma matrices used for calculation of CWRES

are non zero, and the NONMEM 6.2 outputs for these matrices are zero

matrices. The zero matrices seems to be one of the problems in

calculation of CWRES.

I saw in one thread that Tom Ludden mentioned that NONMEM 6.2 can output

the matrices used for calculation of CWRES directly in table format

without using the verbatim code. Has anybody used that function in 6.2

and would be willing to share the code.

Any help would be much appreciated.

Regards,

Susan

Received on Thu Nov 20 2008 - 22:18:12 EST