NONMEM Users Network Archive

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How $simulation work with $estimation

From: Jun Shen <jun.shen.ut>
Date: Tue, 14 Oct 2008 18:01:01 -0500

Dear NMusers,

I wonder how does $Simulation work with $Estimation in NONMEM exactly?
The manual says, NONMEM will simulate DVs and replace the original DVs
based on the parameter initial values. But the initial values are not final
estimates. Does the simulation based on initial values make sense? Do
$Estimation and $Simulation run alternatively? The $Simulation generates a
set of data based on which the parameters are estimated? And then the
predictions are made on the estimated parameters? A little confused.

Appreciate any comment.


Received on Tue Oct 14 2008 - 19:01:01 EDT

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