NONMEM Users Network Archive

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Quantitative criteria for the use of interoccasional variability (IOV) ?

Date: Thu, 23 Oct 2008 12:46:31 -0700


Objective function value (OFV, MVO) decreased by 10 from 6000 when
interoccasional variability (IOV) for three occasions is used.
Standard errors decreased a little bit, but I cannot notice improvements
of diagnostic plots.

Some use 3.84 criteria (a value from chi-square distribution) for one
additional parameter.
I think additional OMEGA SAME for IOV should be handled differently from
theta, omega or sigma.

(Though I don't like the above criteria using chi-square distribution,)
I would like to know if there is similar quantitative criteria for IOV.


Kyun-Seop Bae
Received on Thu Oct 23 2008 - 15:46:31 EDT

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