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FW: NONMEM and g77

From: Destree Maud <Maud.DESTREE>
Date: Mon, 1 Sep 2008 17:32:40 +0200

Dear Justin,
We have validated a NONMEM cluster running on Red Hat, using g77 (gcc =
version 3.4.6 20060404).
We had no problem with this compiler.
Best regards

Maud Destrée

IT Senior Project Leader
IT Global Drug Development
UCB Pharma S.A.
+32-2-386 3012


From: owner-nmusers
On Behalf Of Joachim.Grevel
Sent: Monday, September 01, 2008 3:40 PM
To: justin.wilkins
Cc: nmusers
Subject: Re: [NMusers] NONMEM and g77

Dear Justin,

we are currently validating a NONMEM system on a LINUX platform using =
the gfortran compiler. We call it g77 for the purpose of interacting =
with existing elements of the installation, namely PsN. Our rather =
demanding tests are running quite smoothly but our system is not yet in =
the production phase.

Any other users out there who are happy with gfortran as substitute for =
g77 as compiler?


Joachim GREVEL, Ph.D.
Modeling and Simulation
MERCK SERONO International S.A.
Exploratory Medicine
1202 Geneva
Tel: +41.22.414.4751
Fax: +41.22.414.3059
Email: joachim.grevel

Sent by: owner-nmusers

08/26/2008 07:19 PM

[NMusers] NONMEM and g77


Hi all,

We've run into some problems with NONMEM V and occasionally VI hanging =
during minimization (the "black hole" phenomenon, in which NONMEM stops =
iterating, but never terminates, indefinitely continuing to occupy 99% =
of the CPU it's running on), using GNU g77 3.4.6 on Red Hat Linux - I =
guess this is most likely related to g77's virtually non-existent =
handling of floating point errors.

One way to address this would be to compile the trapfpe.c routine that's =
floating around the Internet into the NONMEM library, I think, but I =
can't help wondering whether there is a more elegant fix (apart from =
writing less buggy NONMEM code).

Has anyone had any recent experience with dealing with this? If we were =
to dump g77 altogether, what other compilers are known to work =
adequately with NONMEM on Linux?

Best regards,
Justin Wilkins
Novartis Pharma AG
CHBS, WSJ-027.1.084
Novartis Pharma AG
Lichtstrasse 35
CH-4056 Basel
Phone: +41 61 324 6549
Fax: +41 61 324 3039
Mobile: +41 76 561 0949
Email : justin.wilkins


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Received on Mon Sep 01 2008 - 11:32:40 EDT

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