NONMEM Users Network Archive

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RE: unbalanced design

From: Willavize, Susan A <susan.a.willavize>
Date: Tue, 2 Sep 2008 14:14:33 -0400

Hi Mark,


This should be true just based on the nature of mixed effects modeling.
If you are not convinced, you may want to try some examples where you
simulate balanced and unbalanced designs and then estimate. :-)


Best Regards,





From: owner-nmusers
On Behalf Of Mark Sale - Next Level Solutions
Sent: Tuesday, September 02, 2008 1:28 PM
To: nmusers
Subject: [NMusers] unbalanced design


Does anyone have a reference to a publication assessing whether mixed
effect modeling (NONMEM in particular) is robust for unbalances studies?
I see if in a number of courses (including the original beginners course
for NONMEM), but can't find a publication.

Mark Sale MD
Next Level Solutions, LLC

Received on Tue Sep 02 2008 - 14:14:33 EDT

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