NONMEM Users Network Archive

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RE: unbalanced design

From: Willavize, Susan A <susan.a.willavize>
Date: Tue, 2 Sep 2008 14:14:33 -0400

Hi Mark,

 

This should be true just based on the nature of mixed effects modeling.
If you are not convinced, you may want to try some examples where you
simulate balanced and unbalanced designs and then estimate. :-)

 

Best Regards,

Susan

 

 

________________________________

From: owner-nmusers
On Behalf Of Mark Sale - Next Level Solutions
Sent: Tuesday, September 02, 2008 1:28 PM
To: nmusers
Subject: [NMusers] unbalanced design

 

Does anyone have a reference to a publication assessing whether mixed
effect modeling (NONMEM in particular) is robust for unbalances studies?
I see if in a number of courses (including the original beginners course
for NONMEM), but can't find a publication.
thanks


Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185


Received on Tue Sep 02 2008 - 14:14:33 EDT

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