NONMEM Users Network Archive

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RE: unbalanced design

From: Wang, Yaning <>
Date: Tue, 2 Sep 2008 14:37:53 -0400

Linear Mixed Models for Longitudinal Data by Geert Verbeke
e> , Geert Molenberghs


Yaning Wang, Ph.D.
Team Leader, Pharmacometrics
Office of Clinical Pharmacology
Office of Translational Science
Center for Drug Evaluation and Research
U.S. Food and Drug Administration
Phone: 301-796-1624

"The contents of this message are mine personally and do not necessarily
reflect any position of the Government or the Food and Drug



From: owner-nmusers
On Behalf Of Mark Sale - Next Level Solutions
Sent: Tuesday, September 02, 2008 1:28 PM
To: nmusers
Subject: [NMusers] unbalanced design

          Does anyone have a reference to a publication assessing whether
mixed effect modeling (NONMEM in particular) is robust for unbalances
studies? I see if in a number of courses (including the original
beginners course for NONMEM), but can't find a publication.

Mark Sale MD
Next Level Solutions, LLC

(image/png attachment: left.letterhead)

Received on Tue Sep 02 2008 - 14:37:53 EDT

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