NONMEM Users Network Archive

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modeling binary observations

From: Zhang, Yi [CNTUS] <YZhang69>
Date: Fri, 12 Sep 2008 13:37:06 -0400

> Dear All :
>
> I'd like to get your opinion on this: when modeling an event (0/1) =
that is caused by an cumulative effect, 1. would cumulative AUC be a =
better predictor than concentration, since CAUC can better capture the =
accumulative process? 2. If CAUC is used, is there good ways to =
implement mechanistic/semi-mechanistic models rather than empirical =
approaches for binary data?
> 3. Can the model results from CAUC be extrapolated to other trial =
designs, why or why not?
> Your input is appreciated. Thanks.
>
> Yi Zhang
> Centocor
>
>
>

Received on Fri Sep 12 2008 - 13:37:06 EDT

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