NONMEM Users Network Archive

Hosted by Cognigen

Revisit parameterization question

From: Tsai, Kuenhi <kuenhi_tsai>
Date: Mon, 15 Sep 2008 11:37:06 -0400

Dear All,

I am working on a data set that the estimates become quite different
under different model assumptions (such as fixed or not fixed ka,
different block structure) using ADVAN4 TRANS1. One suggests me that I
should use TRANS4 to avoid the problem of the high correlations among
ka, Cl, V, k, and k12. When I reviewed the previous NM user discussion
in "reparameterization", the highest "scored" discussion occurred in
2001. I am wondering whether there are any updated discussion and
references on this topic. Any of your help are greatly appreciated.

All the best

Kuenhi Tsai
Notice: This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station,
New Jersey, USA 08889), and/or its affiliates (which may be known
outside the United States as Merck Frosst, Merck Sharp & Dohme or
MSD and in Japan, as Banyu - direct contact information for affiliates is
available at http://www.merck.com/contact/contacts.html) that may be
confidential, proprietary copyrighted and/or legally privileged. It is
intended solely for the use of the individual or entity named on this
message. If you are not the intended recipient, and have received this
message in error, please notify us immediately by reply e-mail and
then delete it from your system.
Received on Mon Sep 15 2008 - 11:37:06 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.